Associations of reproductive factors with postmenopausal follicle stimulating hormone

Women's Midlife Health

Table 3 Beta-coefficients for the association of pregnancy-related factors with follicle-stimulating hormone levels among n = 588 postmenopausal women aged 53–73 who were not using hormone therapy. Kuopio Ischaemic Heart Disease Risk Factor Study, 1998–2001

		Unadjusted		Multivariable Model 1^a		Multivariable Model 2^b
Pregnancy-related characteristic	n	beta (SE)	P	beta (SE)	P	beta (SE)	P
Number of full-term pregnancies
0	76	1.9 (2.6)	0.47	2.5 (2.4)	0.30	2.2 (2.5)	0.39
1	94	0.7 (2.4)	0.79	2.1 (2.2)	0.35	2.9 (2.3)	0.21
2	175	referent		referent		referent
3	128	-5.5 (2.2)	0.01	-4.0 (2.0)	0.05	-3.6 (2.1)	0.08
≥ 4	128	-3.3 (2.3)	0.16	-0.8 (2.2)	0.71	-1.6 (2.3)	0.48
per pregnancy		-1.2 (0.5)	0.009	-0.9 (0.4)	0.04	-1.0 (0.5)	0.03
Age at first birth (years)
< 20	50	0.5 (3.0)	0.86	-0.9 (2.7)	0.75	-1.1 (2.7)	0.70
20—24	253	referent		referent		referent
25—29	145	-2.5 (2.0)	0.21	-1.9 (1.8)	0.29	-2.1 (1.8)	0.26
≥ 30	59	-4.9 (2.8)	0.08	-3.4 (2.5)	0.17	-3.8 (2.6)	0.15
per 1 year		-0.3 (0.2)	0.07	-0.2 (0.2)	0.18	-0.3 (0.2)	0.16
Cross-classification of pregnancies by age at first birth
0	76	-1.2 (2.7)	0.65	-0.1 (2.5)	0.96	-0.9 (2.6)	0.72
1–2 pregnancies, < 25 years old	132	referent		referent		referent
3 + pregnancies, < 25 years old	171	-6.4 (2.2)	0.004	-3.8 (2.0)	0.06	-4.4 (2.1)	0.03
1–2 pregnancies, ≥ 25 years old	135	-5.4 (2.3)	0.02	-2.8 (2.1)	0.18	-3.3 (2.2)	0.13
3 + pregnancies, ≥ 25 years old	69	-9.7 (2.8)	0.0006	-7.3 (2.6)	0.01	-7.8 (2.6)	0.003
Number of miscarriages^c		-2.7 (1.2)	0.03	-2.9 (1.1)	0.01	-2.7 (1.2)	0.02
Number of induced abortions^c		0.9 (1.9)	0.63	-0.7 (1.7)	0.68	-0.01 (1.9)	0.995

^aAdjusted for year of enrollment, age (years), estradiol (pmol/L), testosterone (nmol/L), and sex hormone binding globulin (nmol/L)
^bAdjusted for covariates in MV 1 and body mass index (continuous, kg/m²), waist-to-hip ratio (quartiles), physical activity (MET hours/day), alcohol intake (g/week), currents smoking (yes, no), pack-years of smoking (continuous), duration of OC use (categorical) and duration of past HT use (categorical)
^cbeta per each spontaneous or induced abortion

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