Contribution of common chronic conditions to midlife physical function decline: The Study of Women’s Health Across the Nation

Table 3 Effect of specific prevalent chronic conditions on longitudinal physical function

Model Parameters	Clinically-Meaningful Depressive Symptoms^a		Osteoarthritis		Hypertension		Diabetes
Model Parameters	IRR^b	95% CI	IRR	95% CI	IRR	95% CI	IRR	95% CI
Number of Other Conditions	0.933	0.922, 0.944	0.954	0.943, 0.966	0.934	0.923, 0.945	0.941	0.931, 0.951
Time in Years	0.996	0.996, 0.997	0.996	0.995, 0.996	0.996	0.995, 0.996	0.995	0.994, 0.995
Condition of Interest	1.000	0.979, 1.021	0.936	0.913, 0.958	1.006	0.984, 1.029	0.990	0.951, 1.029
Condition of Interest x Time	0.996	0.995, 0.966	0.995	0.994, 0.996	0.995	0.994, 0.996	0.994	0.992, 0.996
Model Parameters	Osteoporosis		Cancer		Heart Disease		Stroke
Model Parameters	IRR	95% CI	IRR	95% CI	IRR	95% CI	IRR	95% CI
Number of other conditions	0.947	0.937, 0.957	0.941	0.931, 0.950	0.951	0.942, 0.961	0.945	0.935, 0.954
Time in Years	0.994	0.994, 0.995	0.995	0.994, 0.995	0.995	0.994, 0.995	0.995	0.994, 0.995
Condition of Interest	0.876	0.825, 0.927	0.985	0.932, 1.037	0.815	0.754, 0.876	0.911	0.817, 1.006
Condition of Interest x Time	1.001	0.999, 1.004	1.001	0.999, 1.003	0.998	0.995, 1.001	0.992	0.987, 0.997

Note: Models were adjusted for covariates, including age, race/ethnicity, financial strain, marital status, education, menopausal status, hormone use, smoking, body mass index, health status, bodily pain, fracture history, and physical activity. ^aClinically relevant depressive symptoms, defined as Center for Epidemiologic Studies Depression Scale score of ≥16 points. ^bIRR: Incident rate ratio. To obtain percent differences in physical function associated with each model parameter, subtract the IRR from 1 and multiply by 100

ISSN: 2054-2690