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Table 5 Association analysis of prevalence ratios for clinical and metabolic variables and hs-CRP ≥3 mg/l

From: C-reactive protein gene rs1205 polymorphism is associated with low-grade chronic inflammation in postmenopausal women

 

Model 1

 

Model 2

 

Variable

PR (95% CI)

p-value

PR (95% CI)

p-value

rs 1205

 CC

1.64 (1.15–2.33)

0.006

1.53 (1.07–2.18)

0.018

 T carriers

1

 

1

 

MS

 Yes

1.50 (1.05–2.15)

0.025

1.19 (0.79–1.80)

0.404

 No

1

 

1

 

Age, years

1.03 (1.01–1.06)

0.024

1.02 (0.99–1.06)

0.224

IL6, pg/mL

1.03 (1.01–1.05)

0.003

1.02 (0.99–1.04)

0.052

HOMA-IR

1.07 (0.99–1.16)

0.085

  

SBP, mmHg

1.01 (1.002–1.02)

0.013

1.00 (0.99–1.02)

0.967

HDL-c, mg/dl

0.98 (0.97–0.99)

0.024

1.00 (0.98–1.02)

0.943

Triglycerides, mg/dl

1.001 (1.000–1.002)

0.052

  

Insulin, μUI/ml

1.01 (0.99–1.03)

0.122

  

HT

 Yes

0.66 (0.42–1.04)

0.072

  

 No

1

   

WC

  < 88 cm

1

 

1

 

  ≥ 88 cm

2.46 (1.67–3 64)

< 0.001

2.45 (1.66–3.60)

< 0.001

  1. hs-CRP high-sensitivity C-reactive protein, SBP systolic blood pressure, HT hormone therapy, MS metabolic syndrome, WC waist circumference, HOMA-IR homeostatic model assessment, IL6 interleukin 6, PR prevalence ratio, CI confidence interval
  2. Model 1: PR for each variable
  3. Model 2: multivariable Poisson regression including all the variables that were significant in the univariable analysis. Only the polymorphism and waist circumference remained significant in the final model
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Women's Midlife Health

ISSN: 2054-2690

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