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Table 4 Natural direct and indirect effects of intimate partner violence on the age at natural menopause and the proportion mediated through smoking (n = 6138)a

From: The role of smoking in the relationship between intimate partner violence and age at natural menopause: a mediation analysis

  ORNDE (95% CI) ORNIE (95% CI) ORTE (95% CI) Proportion mediated by smoking (%)
Early menopause (ANM <45 vs. ≥45 years)
 Mediator: smoking
  Smoking status (5 categories) 1.31 (1.02–1.68) 1.14 (1.09–1.18) 1.49 (1.16–1.90) 36.7
  Current vs. non-current smoking (2 categories) 1.34 (1.04–1.72) 1.13 (1.08–1.18) 1.51 (1.18–1.93) 33.7
  βNDE (95% CI) βNIE (95% CI) βTE (95% CI) Proportion mediated by smoking (%)
Continuous ANM
 Mediator: smoking
  Smoking status (5 categories) −0.38 (−0.68 to −0.08) −0.22 (−0.28 to −0.16) −0.60 (−0.89 to −0.30) 37.0
  Current vs. non-current smoking (2 categories) −0.41 (−0.71 to −0.11) −0.18 (−0.23 to −0.12) −0.59 (−0.94 to −0.24) 29.8
  1. ANM age at natural menopause, NDE natural direct effect, NIR natural indirect effect, TE total effect
  2. aAll estimates were adjusted for education level, income difficulties, and age at menarche. The mediation analysis was performed by fitting a logistic regression model for the binary outcome (ANM <45 vs. ≥45 years) and a linear regression model for the continuous ANM and fitting a linear or logistic regression model for the ordinal or binary mediator. The proportion mediated was calculated as [(ORNDE (ORNIE – 1)] / [ORNDE × ORNIE –1] × 100% for the binary outcome or (βNIETE) × 100% for the continuous outcome